Ethanolamine → 5-bromo-N-(2-hydroxyethyl)-2-(methylamino)pyridine-3-sulfonamide

反応式

[Br:1][C:2]1[CH:3]=[C:4]([S:10](Cl)(=[O:12])=[O:11])[C:5]([NH:8][CH3:9])=[N:6][CH:7]=1.BrC1C=CC(NC)=NC=1.[NH2:23][CH2:24][CH2:25][OH:26]>>[Br:1][C:2]1[CH:3]=[C:4]([S:10]([NH:23][CH2:24][CH2:25][OH:26])(=[O:12])=[O:11])[C:5]([NH:8][CH3:9])=[N:6][CH:7]=1

参加物

反応物 3

HCID 700Ethanolamine

HCID 156456635-Bromo-N-methylpyridin-2-amine

HCID 866478215-Bromo-2-(methylamino)pyridine-3-sulfonyl chloride

生成物 1

HCID 668205615-bromo-N-(2-hydroxyethyl)-2-(methylamino)pyridine-3-sulfonamide

実験手順

Prepared according to the methods described in reagent preparation 25 using 5-bromo-2-(methylamino)pyridine-3-sulfonyl chloride (prepared from 5-bromo-N-methylpyridin-2-amine using analogous conditions to those described in WO2008144463) and 2-aminoethanol in step 1.

後処理

customPrepared

出典と根拠

ORDレコード: ord-10afbe0e984e40d791253d8fe910203b
出典データセット: uspto-grants-2014_02
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08648066B2

反応ノート

読み込み中…