Ethyl Acetate → 6-Bromo-3 4-dihydro-4,4-dimethyl-8-vinylspiro[2H-1-benzopyran-2,1'-cyclopropane]

HRID 24111

反応式

HRID 24111 の反応式
[CH2:1]=P(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1.[Br:21][C:22]1[CH2:23][C:24](=[C:36]=O)[C:25]2[O:32][C:29]3([CH2:31][CH2:30]3)[CH2:28][C:27]([CH3:34])([CH3:33])[C:26]=2[CH:35]=1.C(OCC)(=O)C>CCCCCC>[Br:21][C:22]1[CH:23]=[C:24]([CH:36]=[CH2:1])[C:25]2[O:32][C:29]3([CH2:31][CH2:30]3)[CH2:28][C:27]([CH3:34])([CH3:33])[C:26]=2[CH:35]=1

参加物

5

反応物 3

HCID 8857Ethyl AcetateHCID 137960MethylenetriphenylphosphoraneHCID 181779686-bromo-8-carbonyl-3,4-dihydro-4,4-dimethylspiro [2H-1-benzopyran-2,1'-cyclopropane]2 回

生成物 1

HCID 225688556-Bromo-3 4-dihydro-4,4-dimethyl-8-vinylspiro[2H-1-benzopyran-2,1'-cyclopropane]

試薬・触媒・溶媒 1

HCID 8058Hexane溶媒

実験手順

Following general procedure N and using A solution of methylidene triphenyl phosphorane [generated from methyl triphenylphosphonium bromide (7 g, 20 mmol) and 1.6M solution of n-butyl lithium in hexanes (11.8 mL, 19 mmol)], 6-bromo-8-carbonyl-3,4-dihydro-4,4-dimethylspiro[2H-1-benzopyran-2,1′-cyclopropane](Intermediate 40, 2.06 g, 7 mmol) followed by flash column chromatography over silica gel (230-400 mesh) using 1-2% ethyl acetate in hexane as the eluent, the title compound was obtained as a clear oil (1.36 g, 66%).

出典と根拠

ORDレコード
ord-32d9f729b81e4268b027aedee27a797c
出典データセット
uspto-grants-2005_02
特許番号
US06855512B2

関連ノート

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