Methanol → Methyl 6-amino-2-methylpyridine-3-carboxylate

HRID 2411164ノート

反応式

HRID 2411164 の反応式
[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[C:4]([CH3:11])[N:3]=1.S(=O)(=O)(O)O.[OH-].[Na+].[CH3:19]O>>[NH2:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([O:8][CH3:19])=[O:7])=[C:4]([CH3:11])[N:3]=1

参加物

5

反応物 4

HCID 887MethanolHCID 1118Sulfuric AcidHCID 14798Sodium HydroxideHCID 288755296-Amino-2-methylpyridine-3-carboxylic acid

生成物 1

HCID 55252884Methyl 6-amino-2-methylpyridine-3-carboxylate

実験手順

6-Amino-2-methylnicotinic acid (1.00 g) was suspended in methanol (15 mL), concentrated sulfuric acid (0.5 mL) was added, and the mixture was stirred with heating under reflux for 18 hr. The reaction mixture was cooled, aqueous sodium hydroxide solution was added, and the mixture was extracted with chloroform. The organic layer was washed with saturated brine, and the solvent was evaporated to give the title compound (0.82 g).

後処理

  1. temperaturewith heating
  2. temperatureunder reflux for 18 hr
  3. temperatureThe reaction mixture was cooled
  4. extractionthe mixture was extracted with chloroform
  5. washThe organic layer was washed with saturated brine
  6. customthe solvent was evaporated

出典と根拠

ORDレコード
ord-0abe182b5c4c4cc68431c8cbc27e4d99
出典データセット
uspto-grants-2014_08
特許番号
US08816079B2

反応ノート

読み込み中…