Sodium Iodide → [4-(2,4-Dimethylphenyl)piperazin-1-yl](6-iodopyridin-3-yl)methanone

HRID 2411298ノート

反応式

HRID 2411298 の反応式
Br[C:2]1[N:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][N:13]([C:16]3[CH:21]=[CH:20][C:19]([CH3:22])=[CH:18][C:17]=3[CH3:23])[CH2:12][CH2:11]2)=[O:9])=[CH:4][CH:3]=1.[I-:24].[Na+]>[Cu]I>[CH3:23][C:17]1[CH:18]=[C:19]([CH3:22])[CH:20]=[CH:21][C:16]=1[N:13]1[CH2:14][CH2:15][N:10]([C:8]([C:5]2[CH:6]=[N:7][C:2]([I:24])=[CH:3][CH:4]=2)=[O:9])[CH2:11][CH2:12]1

参加物

4

反応物 2

HCID 5238Sodium IodideHCID 58484755HCID 58484755、化合物

生成物 1

HCID 86676763[4-(2,4-Dimethylphenyl)piperazin-1-yl](6-iodopyridin-3-yl)methanone収率 62.1%

試薬・触媒・溶媒 1

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)触媒

実験手順

Using (6-bromopyridin-3-yl)[4-(2,4-dimethylphenyl)piperazin-1-yl]methanone (487 mg) described in Preparation Example 115, sodium iodide (389 mg) and copper(I) iodide (123 mg) and by the reaction and treatment in the same manner as in Preparation Example 154, the title compound (340.6 mg) was obtained.

出典と根拠

ORDレコード
ord-e7f19f13b8dd46d7b4335aae1fe0ab00
出典データセット
uspto-grants-2014_08
特許番号
US08816079B2

反応ノート

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