6-Bromonicotinic acid → (6-Bromopyridin-3-yl)[4-(p-tolyloxy)piperidin-1-yl]methanone

HRID 2411330

反応式

HRID 2411330 の反応式
[C:1]1([CH3:14])[CH:6]=[CH:5][C:4]([O:7][CH:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[CH:3][CH:2]=1.[Br:15][C:16]1[CH:24]=[CH:23][C:19]([C:20](O)=[O:21])=[CH:18][N:17]=1>>[Br:15][C:16]1[N:17]=[CH:18][C:19]([C:20]([N:11]2[CH2:12][CH2:13][CH:8]([O:7][C:4]3[CH:3]=[CH:2][C:1]([CH3:14])=[CH:6][CH:5]=3)[CH2:9][CH2:10]2)=[O:21])=[CH:23][CH:24]=1

参加物

3

反応物 2

HCID 2389326-Bromonicotinic acidHCID 38374974-(4-Methylphenoxy)piperidine

生成物 1

HCID 58484591(6-Bromopyridin-3-yl)[4-(p-tolyloxy)piperidin-1-yl]methanone収率 99.9%

実験手順

Using 4-(p-tolyloxy)piperidine (765 mg) and 6-bromonicotinic acid (808 mg) and by the reaction and treatment in the same manner as in Preparation Example 118, the title compound (1.5 g) was obtained.

後処理

  1. customby the reaction and treatment in the same manner
  2. customas in Preparation Example 118

出典と根拠

ORDレコード
ord-e46681dc325d47bfaf2d19e9ad6d59c7
出典データセット
uspto-grants-2014_08
特許番号
US08816079B2

関連ノート

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