Methyl iodide → 1-{4-[4-(3,5-Dimethylpyridin-2-yl)piperazine-1-carbonyl]-2-fluorophenyl}-3,5-dimethylimidazolidine-2,4-dione
反応式
[CH3:1][C:2]1[C:3]([N:9]2[CH2:14][CH2:13][N:12]([C:15]([C:17]3[CH:22]=[CH:21][C:20]([N:23]4[CH:27]([CH3:28])[C:26](=[O:29])[NH:25][C:24]4=[O:30])=[C:19]([F:31])[CH:18]=3)=[O:16])[CH2:11][CH2:10]2)=[N:4][CH:5]=[C:6]([CH3:8])[CH:7]=1.[CH3:32]I>>[CH3:1][C:2]1[C:3]([N:9]2[CH2:10][CH2:11][N:12]([C:15]([C:17]3[CH:22]=[CH:21][C:20]([N:23]4[CH:27]([CH3:28])[C:26](=[O:29])[N:25]([CH3:32])[C:24]4=[O:30])=[C:19]([F:31])[CH:18]=3)=[O:16])[CH2:13][CH2:14]2)=[N:4][CH:5]=[C:6]([CH3:8])[CH:7]=1参加物
3
実験手順
Using 1-{4-[4-(3,5-dimethylpyridin-2-yl)piperazine-1-carbonyl]-2-fluorophenyl}-5-methylimidazolidine-2,4-dione (90 mg) described in Example 528 and methyl iodide (17 μL) and by the reaction and treatment in the same manner as in Example 36, the title compound (22 mg) was obtained.
出典と根拠
- ORDレコード
- ord-4456186a3c864062b92ace45c92ace3c
- 出典データセット
- uspto-grants-2014_08
- 特許番号
- US08816079B2
反応ノート
読み込み中…