Hydrochloric Acid → HCID 20432562、化合物

HRID 2412393

反応式

HRID 2412393 の反応式
[CH:1]1([C:7]([N:9]2[CH2:14][CH2:13][N:12](CC3C=CC=CC=3)[CH2:11][CH2:10]2)=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[ClH:22].[H][H]>C(O)C.[Pd]>[ClH:22].[CH:1]1([C:7]([N:9]2[CH2:10][CH2:11][NH:12][CH2:13][CH2:14]2)=[O:8])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 562738(4-Benzylpiperazin-1-yl)(cyclohexyl)methanoneHCID 178418361HCID 178418361、化合物

生成物 1

HCID 20432562HCID 20432562、化合物

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

14.3 g (0.05 mole) of 1-cyclohexanecarbonyl-4-benzylpiperazine dissolved in 250 ml of ethanol and acidified with conc. HCl was treated with hydrogen over a palladium catalyst at 1500 psi and 100° C. The catalyst was removed by filtration and the solvent removed under reduced pressure. The residue was dissolved in isopropanol. On short standing a white crystalline precipitate appeared which was collected by filtration to give 10.0 g of 1-cyclohexanecarbonylpiperazine hydrochloride.

後処理

  1. customThe catalyst was removed by filtration
  2. customthe solvent removed under reduced pressure
  3. dissolutionThe residue was dissolved in isopropanol
  4. filtrationwas collected by filtration

出典と根拠

ORDレコード
ord-851606e24c71421794b1a3af844c8fae
出典データセット
uspto-grants-1985_01
特許番号
US04492698

関連ノート

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