Methanesulfonyl chloride → 2-Guanidino-4-(methanesulfonyloxymethyl)thiazole
反応式
[NH:1]([C:5]1[S:6][CH:7]=[C:8]([CH2:10][OH:11])[N:9]=1)[C:2]([NH2:4])=[NH:3].[CH3:12][S:13](Cl)(=[O:15])=[O:14]>N1C=CC=CC=1>[NH:1]([C:5]1[S:6][CH:7]=[C:8]([CH2:10][O:11][S:13]([CH3:12])(=[O:15])=[O:14])[N:9]=1)[C:2]([NH2:4])=[NH:3]参加物
4
実験手順
To a solution of 2-guanidino-4-hydroxymethylthiazole (0.86 g) in pyridine (6 ml) is gradually added methanesulfonyl chloride (0.6 g) under ice cooling, and the resultant mixture is stirred at room temperature for 2 hours. The reaction mixture is concentrated in vacuum, and the residual oil is chromatographed on a column of silica gel, which is eluted with methanol. The eluate is concentrated in vacuum to give 2-guanidino-4-(methanesulfonyloxymethyl)thiazole (1.2 g) as an oil. The yield is 96%.
後処理
- concentrationThe reaction mixture is concentrated in vacuum
- customthe residual oil is chromatographed on a column of silica gel, which
- washis eluted with methanol
- concentrationThe eluate is concentrated in vacuum
出典と根拠
- ORDレコード
- ord-306843c60df84c56a8d782f69ef0f2b1
- 出典データセット
- uspto-grants-1985_01
- 特許番号
- US04492794
反応ノート
読み込み中…