Methanol → Propanoic acid, 3-chloro-2,2-dimethyl-, methyl ester

HRID 2412529ノート

反応式

HRID 2412529 の反応式
[Cl:1][CH2:2][C:3]([CH3:8])([CH3:7])[C:4](Cl)=[O:5].C(N(CC)CC)C.[CH3:16][OH:17]>>[Cl:1][CH2:2][C:3]([CH3:8])([CH3:7])[C:4]([O:17][CH3:16])=[O:5]

参加物

4

反応物 3

HCID 887MethanolHCID 8471TriethylamineHCID 613453-Chloro-2,2-dimethylpropanoyl chloride

生成物 1

HCID 543185Propanoic acid, 3-chloro-2,2-dimethyl-, methyl ester

実験手順

219 g of chloropivaloyl chloride was added drop-by-drop to a chilled (0°-5° C.), stirred solution of 141.4 g of triethylamine in 320 g of anhydrous methanol. The resulting mixture was warmed to room temperature in one hour, and most of the methanol was evaporated under reduced pressure. The residue was drowned in water and extracted with ether. The extract was dried (MgSO4) and the solvent was evaporated. The residue was distilled to give methyl 3-chloro-2,2-dimethylpropionate (2A), b.p.: 40°-50° C. (14 Torr.).

後処理

  1. temperaturea chilled (0°-5° C.)
  2. custommost of the methanol was evaporated under reduced pressure
  3. extractionextracted with ether
  4. dry with materialThe extract was dried (MgSO4)
  5. customthe solvent was evaporated
  6. distillationThe residue was distilled

出典と根拠

ORDレコード
ord-1f3bcff321814e5ab32196f36e7b65f5
出典データセット
uspto-grants-1985_01
特許番号
US04493728

反応ノート

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