Hydrogen Bromide → HCID 54162042、化合物

HRID 2412864ノート

反応式

HRID 2412864 の反応式
[BrH:1].[F:2][CH:3]1[CH2:8][CH2:7][O:6][C:4]1=[O:5].[CH2:9](O)[CH3:10]>>[CH2:9]([O:6][C:4](=[O:5])[CH:3]([F:2])[CH2:8][CH2:7][Br:1])[CH3:10]

参加物

4

反応物 3

HCID 260Hydrogen BromideHCID 702EthanolHCID 11412352α-Fuluoro-γ-butyrolactone

生成物 1

HCID 54162042HCID 54162042、化合物収率 34%

実験手順

Hydrogen bromide gas was added over a period of about 30 minutes to a solution of 2-fluorobutyrolactone (1.8 g) in ethanol (15 ml) at 0° C. The reaction mixture was left at room temperature for 3 days, after which it was evaporated in vacuo. The residue was dissolved in icewater, the solution was neutralized with sodiumcarbonate and extracted with ether. The ether solution was washed with an aqueous saturated Na2SO4 solution, dried over Na2SO4 and evaporated to give 4-bromo-2-fluorobutyric acid ethyl ester (1.26 g, 34%). nD20 =1.4698. 1H-NMR (CDCl3, MeSi)δ: 1.3 (t, J=7 Hz, CH3); 2.1-2.8 (m, CH2); 3.55 (t, J=7 Hz, CH2Br); 4.3 (q, J=7 Hz, CH2); 4.75 and 5.55 (two triplets, J=6 Hz, CHF, JCHF =50 Hz).

後処理

  1. customafter which it was evaporated in vacuo
  2. dissolutionThe residue was dissolved in icewater
  3. extractionextracted with ether
  4. washThe ether solution was washed with an aqueous saturated Na2SO4 solution
  5. dry with materialdried over Na2SO4
  6. customevaporated

出典と根拠

ORDレコード
ord-44ae91d2a4b34399aa27dd4ba5215963
出典データセット
uspto-grants-1985_01
特許番号
US04495190

反応ノート

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