Hydrazine hydrate (1:1) → 2-Chloro-3-hydrazino-6-methoxyquinoxaline

HRID 2412917ノート

反応式

HRID 2412917 の反応式
[Cl:1][C:2]1[C:11](Cl)=[N:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([O:13][CH3:14])[CH:8]=2)[N:3]=1.O.[NH2:16][NH2:17]>C(O)C>[Cl:1][C:2]1[C:11]([NH:16][NH2:17])=[N:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([O:13][CH3:14])[CH:8]=2)[N:3]=1

参加物

4

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 6842272,3-Dichloro-6-methoxyquinoxaline

生成物 1

HCID 133856792-Chloro-3-hydrazino-6-methoxyquinoxaline収率 97%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

2,3-Dichloro-6-methoxyquinoxaline (4.2 g., 0.018 mole), the product of Preparation E(b), and 2.7 ml. of hydrazine hydrate in 100 ml. of ethanol were heated under reflux for 4 hours and stirred at room temperature overnight. The precipitate was removed by filtration and washed with ethanol to afford 3.9 g. (97% yield) of 2-chloro-3-hydrazino-6-methoxyquinoxaline, m.p. <250° C. Mass spectrum: m/e, 224 (P); m/e 226 (P+2).

後処理

  1. temperatureunder reflux for 4 hours
  2. customThe precipitate was removed by filtration
  3. washwashed with ethanol
  4. customto afford 3.9 g

出典と根拠

ORDレコード
ord-23598780aee6489080400c6462e25ea0
出典データセット
uspto-grants-1985_01
特許番号
US04495187

反応ノート

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