Chloroacetyl chloride → 2-Chloro-N-(4-chlorobenzenesulfonyl)acetamide

HRID 2413040

反応式

HRID 2413040 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([NH2:11])(=[O:10])=[O:9])=[CH:4][CH:3]=1.[Cl:12][CH2:13][C:14](Cl)=[O:15]>>[Cl:12][CH2:13][C:14]([NH:11][S:8]([C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=1)(=[O:9])=[O:10])=[O:15]

参加物

3

反応物 2

HCID 6577Chloroacetyl chlorideHCID 668244-Chlorobenzenesulfonamide

生成物 1

HCID 6765032-Chloro-N-(4-chlorobenzenesulfonyl)acetamide

実験手順

The reactant N-chloroacetyl 4-chlorobenzene sulfonamide was prepared by mixing 30.0 g of 4-chlorobenzene sulfonamide and 60.0 ml of chloroacetylchloride. The mixture was refluxed for 6 hours, allowed to cool, and stand at room temperature overnight. The crystalline product was removed by filtration, washed repeatedly with hexane, and dried. The product consisted of 32.5 g of reactant (m.p. 122°-124° C.). Structure was confirmed by IR and NMR.

後処理

  1. temperatureThe mixture was refluxed for 6 hours
  2. temperatureto cool
  3. customThe crystalline product was removed by filtration
  4. washwashed repeatedly with hexane
  5. customdried

出典と根拠

ORDレコード
ord-6ff650ebc91f4cc8b8beabbdb27ea031
出典データセット
uspto-grants-1985_01
特許番号
US04495365

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