Hydrogen Bromide → 79412-27-4

HRID 2413783ノート

反応式

HRID 2413783 の反応式
Cl.[CH2:2]([N:5]1[CH2:10][CH2:9][CH2:8][CH:7]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([O:17]C)[CH:12]=2)[CH2:6]1)[CH2:3][CH3:4].[BrH:19]>>[BrH:19].[CH2:2]([N:5]1[CH2:10][CH2:9][CH2:8][CH:7]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([OH:17])[CH:12]=2)[CH2:6]1)[CH2:3][CH3:4]

参加物

3

反応物 2

HCID 260Hydrogen BromideHCID 23045624HCID 23045624、化合物

生成物 1

HCID 2304564779412-27-4収率 86%

実験手順

N-Propyl-3-(3-methoxyphenyl)piperidine hydrochloride (7.0 g, 0.026 mol) was suspended in 48% HBr (200 ml). The mixture was refluxed under nitrogen for 3 h. The hydrobromic acid was evaporated and the residue was recrystallized from ethanol/ether, yielding the pure product (6.7 g, 86%) mp. 146°-7.5° C.

後処理

  1. temperatureThe mixture was refluxed under nitrogen for 3 h
  2. customThe hydrobromic acid was evaporated
  3. customthe residue was recrystallized from ethanol/ether

出典と根拠

ORDレコード
ord-ca3a7c07f0de4422b7c1bde1227022d2
出典データセット
uspto-grants-1988_01
特許番号
US04719219

反応ノート

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