Sodium Hydroxide → 2-(4-Nitrophenyl)propionic acid

HRID 2413908ノート

反応式

HRID 2413908 の反応式
[CH3:1][C:2]([C:13]1[CH:18]=[CH:17][C:16]([N+:19]([O-:21])=[O:20])=[CH:15][CH:14]=1)(C(OCC)=O)[C:3]([O:5]CC)=[O:4].[OH-].[Na+]>C(O)C.O>[N+:19]([C:16]1[CH:15]=[CH:14][C:13]([CH:2]([CH3:1])[C:3]([OH:5])=[O:4])=[CH:18][CH:17]=1)([O-:21])=[O:20]

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 12380744Diethyl methyl(4-nitrophenyl)propanedioate

生成物 1

HCID 892442-(4-Nitrophenyl)propionic acid収率 68.8%

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒2 回

実験手順

147 g of the crude diethyl 2-methyl-2-(4-nitrophenyl)-malonate was dissolved in 600 ml of ethanol, and to this was added a solution of 42.4 g (0.846 mole) of 93% sodium hydroxide in 400 ml of water and the solution was reacted at 50° C. for 3 hours. After that, to the reaction mixture was added 1 l of water and the formed oily substance and an aqueous layer were separated. The aqueous layer was acidified with conc. hydrochloric acid and was extracted with 700 ml of ethyl acetate. The ethyl acetate layer was washed with a saturated solution of sodium chloride and dried over anhydrous magnesium sulfate. After filtering out magnesium sulfate, ethyl acetate was distilled off to give 66.8 g of crude 2-(4-nitrophenyl)propionic acid.

後処理

  1. customthe solution was reacted at 50° C. for 3 hours
  2. customthe formed oily substance and an aqueous layer were separated
  3. extractionwas extracted with 700 ml of ethyl acetate
  4. washThe ethyl acetate layer was washed with a saturated solution of sodium chloride
  5. dry with materialdried over anhydrous magnesium sulfate
  6. filtrationAfter filtering out magnesium sulfate, ethyl acetate
  7. distillationwas distilled off

出典と根拠

ORDレコード
ord-ebc26e7989a84217bf46f5446e02ca5f
出典データセット
uspto-grants-1988_01
特許番号
US04720506

反応ノート

読み込み中…