Veratrole → N-[2-[bis(1-methylethyl)amino]ethyl]-3,4-dimethoxy-N-(1-methylethyl)-benzenesulfonamide

HRID 2413999ノート

反応式

HRID 2413999 の反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([S:11](Cl)(=[O:13])=[O:12])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].C1(OC)C(=CC=CC=1)OC.ClS(O)(=O)=O.[CH:30]([N:33]([CH:40]([CH3:42])[CH3:41])[CH2:34][CH2:35][NH:36][CH:37]([CH3:39])[CH3:38])([CH3:32])[CH3:31]>>[CH3:42][CH:40]([N:33]([CH:30]([CH3:32])[CH3:31])[CH2:34][CH2:35][N:36]([CH:37]([CH3:39])[CH3:38])[S:11]([C:5]1[CH:6]=[CH:7][C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=1)(=[O:13])=[O:12])[CH3:41]

参加物

5

反応物 4

HCID 7043VeratroleHCID 24638Chlorosulfonic acidHCID 66797N,N,N'-TriisopropylethylenediamineHCID 27341833,4-Dimethoxybenzenesulfonyl chloride

生成物 1

HCID 14096741N-[2-[bis(1-methylethyl)amino]ethyl]-3,4-dimethoxy-N-(1-methylethyl)-benzenesulfonamide

実験手順

3,4-Dimethoxybenzene sulfonyl chloride, prepared from veratrole and chlorosulfonic acid was reacted with N,N,N'-triisopropyl ethylene diamine following the procedure of Example 1. The reaction was worked up and the crude product chromatographed on alumina with ethyl acetate. The pure product was obtained, m.r. 69°-71° C.

後処理

  1. customthe crude product chromatographed on alumina with ethyl acetate
  2. customThe pure product was obtained
  3. custom69°-71° C.

出典と根拠

ORDレコード
ord-4187c3dcec7a4b8b91d5168270a89606
出典データセット
uspto-grants-1988_01
特許番号
US04720580

反応ノート

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