Sodium borohydride → (3,4-Dimethoxy-5-propylphenyl)methanol
反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:8]=[C:9]([CH2:13][CH2:14][CH3:15])[C:10]=1[O:11][CH3:12])[CH:6]=[O:7].[BH4-].[Na+]>CC(O)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:6][OH:7])[CH:8]=[C:9]([CH2:13][CH2:14][CH3:15])[C:10]=1[O:11][CH3:12]参加物
4
実験手順
A solution of 3,4-dimethoxy-5-propylbenzaldehyde (11 g) and sodium borohydride (2 g) in 2-propanol (100 ml) was stirred at room temperature for 2 hours. The mixture was quenched with 2 N HCl (200 ml) and extracted with ethyl acetate. The organic phase was separated, washed with brine, dried over MgSO4, filtered and evaporated to leave a yellow oil which was purified by Kugelrohr bulb to bulb distillation at 1 mm Hg air bath temperature 150° to give the sub-title compound as a colourless oil (8 g).
後処理
- customThe mixture was quenched with 2 N HCl (200 ml)
- extractionextracted with ethyl acetate
- customThe organic phase was separated
- washwashed with brine
- dry with materialdried over MgSO4
- filtrationfiltered
- customevaporated
- customto leave a yellow oil which
- distillationwas purified by Kugelrohr bulb to bulb distillation at 1 mm Hg air bath temperature 150°
出典と根拠
- ORDレコード
- ord-bc9f22552844456baef6143ed2657022
- 出典データセット
- uspto-grants-1988_01
- 特許番号
- US04720586
反応ノート
読み込み中…