2-Chloroethanol → 1-(2-Hydroxy-ethyl)-piperidine-4-carboxylic acid amide
反応式
Cl[CH2:2][CH2:3][OH:4].C(=O)([O-])[O-].[K+].[K+].[I-].[Na+].[C:13]([CH:16]1[CH2:21][CH2:20][NH:19][CH2:18][CH2:17]1)(=[O:15])[NH2:14]>C(O)C>[OH:4][CH2:3][CH2:2][N:19]1[CH2:20][CH2:21][CH:16]([C:13](=[O:15])[NH2:14])[CH2:17][CH2:18]1参加物
6
実験手順
2-Chloroethanol (23.9 ml), potassium carbonate (82.0 g) and sodium iodide (4.5 g) were added to an ethanol solution (500 ml) of 4-carbamoylpiperidine (35 g), followed by refluxing for 20 hours. After allowing the reaction mixture to cool down to room temperature, it was filtered through Celite (trade mark). The filtrate was concentrated under reduced pressure. After washing the residue, it was dried to obtain 46.6 g of the desired product.
後処理
- temperatureby refluxing for 20 hours
- filtrationit was filtered through Celite (trade mark)
- concentrationThe filtrate was concentrated under reduced pressure
- washAfter washing the residue, it
- customwas dried
出典と根拠
- ORDレコード
- ord-e56d6e7c8f5f4578b3f97d929bf05aa7
- 出典データセット
- uspto-grants-1988_01
- 特許番号
- US04721788
反応ノート
読み込み中…