Triethylamine → Chloride
反応式
[ClH:1].[NH2:2][CH2:3][CH2:4][CH2:5][C:6]1[C:11]2[CH:12]=[C:13]([O:16][CH3:17])[CH:14]=[CH:15][C:10]=2[O:9][CH2:8][CH:7]=1.BrBr.C(N(CC)CC)C>C(OCC)(=O)C>[Cl-:1].[ClH:1].[CH3:17][O:16][C:13]1[CH:14]=[CH:15][C:10]2[O:9][CH2:8][CH:7]3[NH:2][CH2:3][CH2:4][CH:5]=[C:6]3[C:11]=2[CH:12]=1参加物
6
実験手順
To a suspension of 20 g of 4-(3-aminopropyl)-6-methoxy-2H-[1]-benzopyran hydrochloride in 200 ml of ethyl acetate is added 12.5 g of bromine at room temperature. After 15 minutes at room temperature 24 g of triethylamine is added and the reaction mixture is refluxed for 2 hours. After washing with water and drying the solvent is removed in vacuo. The residue chloride to afford 9-methoxy-2,3,4a,5-tetrahydro-4H-[1]-benzopyrano[3,4-b]pyridine hydrochloride, m.p. 285°-286°.
後処理
- temperaturethe reaction mixture is refluxed for 2 hours
- washAfter washing with water
- customdrying the solvent
- customis removed in vacuo
出典と根拠
- ORDレコード
- ord-0bac85fd7f9346e5a36bd4b8176626d7
- 出典データセット
- uspto-grants-1988_01
- 特許番号
- US04721787
反応ノート
読み込み中…