Sodium Iodide → Allyl 3-iodomethylbenzoate
反応式
Cl[CH2:2][C:3]1[CH:4]=[C:5]([CH:12]=[CH:13][CH:14]=1)[C:6]([O:8][CH2:9][CH:10]=[CH2:11])=[O:7].[I-:15].[Na+]>CC(C)=O>[I:15][CH2:2][C:3]1[CH:4]=[C:5]([CH:12]=[CH:13][CH:14]=1)[C:6]([O:8][CH2:9][CH:10]=[CH2:11])=[O:7]参加物
4
実験手順
A solution of allyl 3-(chloromethyl)-benzoate (54.5 g, 0.259 mmol) and sodium iodide (46.56 g, 0.311 mol) in acetone (500 mL) is stirred at room temp. for 6.5 hours, after which time the mixture is filtered. The filtrate is evaporated and the residue is dissolved in diethyl ether (500 mL), then washed with water (1×200 mL), 5% sodium sulfite solution (1×200 mL) and brine (1×200 mL), dried over magnesium sulfate, and evaporated to yield allyl 3-(iodomethyl)-benzoate as a white solid.
後処理
- filtrationafter which time the mixture is filtered
- customThe filtrate is evaporated
- dissolutionthe residue is dissolved in diethyl ether (500 mL)
- washwashed with water (1×200 mL), 5% sodium sulfite solution (1×200 mL) and brine (1×200 mL)
- dry with materialdried over magnesium sulfate
- customevaporated
出典と根拠
- ORDレコード
- ord-91719192555342d1abd3465f6b7c319f
- 出典データセット
- uspto-grants-2004_11
- 特許番号
- US06812237B2
反応ノート
読み込み中…