Water → 1-(4-Bromovaleroyl)-4-methylpiperidine

HRID 2414781ノート

反応式

HRID 2414781 の反応式
[CH3:1][CH:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[Br:8][CH:9]([CH3:15])[CH2:10][CH2:11][C:12](Cl)=[O:13].O>C(#N)C>[Br:8][CH:9]([CH3:15])[CH2:10][CH2:11][C:12]([N:5]1[CH2:6][CH2:7][CH:2]([CH3:1])[CH2:3][CH2:4]1)=[O:13]

参加物

5

反応物 3

HCID 962WaterHCID 693814-MethylpiperidineHCID 22643413HCID 22643413、化合物

生成物 1

HCID 226434181-(4-Bromovaleroyl)-4-methylpiperidine収率 82%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

1.09 g of 4-methylpiperidine was dissolved in 10 ml of acetonitrile and added dropwise with 1.09 g of 4-bromovaleroyl chloride. The reaction mixture was stirred for 2 hours, then poured into water and extracted with ethyl acetate. The organic layer was washed with wafer and dried over sodium sulfate, and then the solvent was evaporated under reduced pressure to obtain 1.07 g of the title compound (yield: 82%).

後処理

  1. extractionextracted with ethyl acetate
  2. washThe organic layer was washed with wafer
  3. dry with materialdried over sodium sulfate
  4. customthe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-be3d31fd80a34a63842c8ba79f41da24
出典データセット
uspto-grants-2004_11
特許番号
US06815455B1

反応ノート

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