Methyl 3-amino-2-methylpropanoate → 3-(4-Methoxy-quinolin-2-ylamino)-2-methyl-propionic acid methyl ester

HRID 2415132ノート

反応式

HRID 2415132 の反応式
[CH3:1][O:2][C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]=[C:5](OS(C(F)(F)F)(=O)=O)[CH:4]=1.[CH3:21][O:22][C:23](=[O:28])[CH:24]([CH3:27])[CH2:25][NH2:26]>C(#N)C>[CH3:21][O:22][C:23](=[O:28])[CH:24]([CH3:27])[CH2:25][NH:26][C:5]1[CH:4]=[C:3]([O:2][CH3:1])[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[N:6]=1

参加物

4

反応物 2

HCID 10486829Methyl 3-amino-2-methylpropanoateHCID 235256351,1,1-Trifluoromethanesulfonic acid 4-methoxyquinolin-2-yl ester

生成物 1

HCID 698371313-(4-Methoxy-quinolin-2-ylamino)-2-methyl-propionic acid methyl ester収率 42%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

A solution of 1,1,1-trifluoromethanesulfonic acid 4-methoxyquinolin-2-yl ester [from Example 1b] (2.03 g, 6.61 mmol) and 3-amino-2-methyl-propionic acid methyl ester (1.5 eq, 1.52 g, 9.91 mmol) in acetonitrile (25 mL) was heated at reflux for five days. It was cooled to room temperature and evaporated to an oil. The crude product was purified via column chromatography on silica (1:1 ethyl acetate/hexane) to give the product (0.75 g, 42%) as an orange oil. [M+H]+ 275.

後処理

  1. temperatureat reflux for five days
  2. customevaporated to an oil
  3. customThe crude product was purified via column chromatography on silica (1:1 ethyl acetate/hexane)

出典と根拠

ORDレコード
ord-58ec150cafc145d59574ae66d93d4135
出典データセット
uspto-grants-2004_11
特許番号
US06818655B2

反応ノート

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