Hydrochloric Acid → HCID 22640723、化合物

HRID 2415134ノート

反応式

HRID 2415134 の反応式
[C:1](/[C:3](=[CH:7]\[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)/[C:4]([NH2:6])=[O:5])#[N:2].Cl>C(O)C.[Pd]>[NH2:2][CH2:1][CH:3]([CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:4]([NH2:6])=[O:5]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 725466BENZALCYANOACETAMIDE

生成物 1

HCID 22640723HCID 22640723、化合物収率 119.5%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A solution of (E)-2cyano-3-phenyl-acrylamide (0.50 g, 2.91 mmol) was dissolved in ethanol (25 mL). Concentrated HCl (1 mL) was added, followed by 10% degussa palladium on carbon (1.0 g). The mixture was subjected to hydrogenation conditions (55 psi) for 24 hours. It was filtered through Celite and concentrated to give the product (0.62 g, 100%) as a white solid. [M+H]+ 179.

後処理

  1. filtrationIt was filtered through Celite
  2. concentrationconcentrated

出典と根拠

ORDレコード
ord-291a905c7d0841f0a7594e8035bd4e58
出典データセット
uspto-grants-2004_11
特許番号
US06818655B2

反応ノート

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