Trifluoroacetic acid → 1-(6-Phenyl-pyridin-2-yl)-piperazine

HRID 2415168ノート

反応式

HRID 2415168 の反応式
[C:1]1([C:7]2[N:12]=[C:11]([N:13]3[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][CH2:14]3)[CH:10]=[CH:9][CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.FC(F)(F)C(O)=O>ClCCl>[C:1]1([C:7]2[N:12]=[C:11]([N:13]3[CH2:18][CH2:17][NH:16][CH2:15][CH2:14]3)[CH:10]=[CH:9][CH:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 68577637Tert-butyl 4-(6-phenylpyridin-2-yl)piperazine-1-carboxylate

生成物 1

HCID 226401851-(6-Phenyl-pyridin-2-yl)-piperazine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of 0.7 g (2.06 mmol) of tert.butyl 4-(6-phenyl-pyridin-2-yl)-piperazine-1-carboxylate and 3 ml of trifluoroacetic acid in 30 ml of dichloromethane is stirred for three hours at ambient temperature. The solvent is then distilled off, the residue is combined with water and made basic with sodium hydroxide solution. It is then extracted with dichloromethane and the organic phase is separated off and dried over sodium sulphate.

後処理

  1. distillationThe solvent is then distilled off
  2. extractionIt is then extracted with dichloromethane
  3. customthe organic phase is separated off
  4. dry with materialdried over sodium sulphate

出典と根拠

ORDレコード
ord-bc06fdb1fa914bbab7af4e3ad94e33e1
出典データセット
uspto-grants-2004_11
特許番号
US06818644B1

反応ノート

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