7-Benzyloxy-2-methyl-4-pyrrolidin-1-yl-quinoline → 2-Methyl-4-pyrrolidin-1-yl-quinolin-7-ol

HRID 2415464ノート

反応式

HRID 2415464 の反応式
C([O:8][C:9]1[CH:18]=[C:17]2[C:12]([C:13]([N:20]3[CH2:24][CH2:23][CH2:22][CH2:21]3)=[CH:14][C:15]([CH3:19])=[N:16]2)=[CH:11][CH:10]=1)C1C=CC=CC=1>CO.[Pd]>[CH3:19][C:15]1[CH:14]=[C:13]([N:20]2[CH2:24][CH2:23][CH2:22][CH2:21]2)[C:12]2[C:17](=[CH:18][C:9]([OH:8])=[CH:10][CH:11]=2)[N:16]=1

参加物

4

反応物 1

HCID 226413107-Benzyloxy-2-methyl-4-pyrrolidin-1-yl-quinoline

生成物 1

HCID 1358041182-Methyl-4-pyrrolidin-1-yl-quinolin-7-ol収率 96.2%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A solution of 13 g of 7-benzyloxy-2-methyl-4-pyrrolidin-1-yl-quinoline, product of example 1, dissolved in 750 ml of MeOH was treated with 4 g of palladium on charcoal (10%) and then hydrogenated at RT for 1.5 h until HPLC analysis indicated the completion of the reaction. The catalyst was filtered off, washed with water) and the solution was concentrated in vacuo. The solid that precipitated was collected by filtration and dried in a high vacuum to give 8.9 g (96.2%) of 2-methyl-4-pyrrolidin-1-yl-quinolin-7-ol as an amorphous yellow solid. ISP mass spectrum, m/e: 229.2 (M+1 calculated for C14H16N2O: 229).

後処理

  1. customthe completion of the reaction
  2. filtrationThe catalyst was filtered off
  3. washwashed with water) and the solution
  4. concentrationwas concentrated in vacuo
  5. customThe solid that precipitated
  6. filtrationwas collected by filtration
  7. customdried in a high vacuum

出典と根拠

ORDレコード
ord-f2f2c1a93a9549eabd0225aceb952929
出典データセット
uspto-grants-2004_11
特許番号
US06818767B2

反応ノート

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