HCID 178428840、化合物 → HCID 178428839、化合物

HRID 2415503ノート

反応式

HRID 2415503 の反応式
C([O:8][C:9]1[CH:18]=[C:17]2[C:12]([C:13]([OH:20])=[CH:14][C:15]([CH3:19])=[N:16]2)=[CH:11][CH:10]=1)C1C=CC=CC=1>CO.[Pd]>[CH3:19][C:15]1[CH:14]=[C:13]([OH:20])[C:12]2[C:17](=[CH:18][C:9]([OH:8])=[CH:10][CH:11]=2)[N:16]=1

参加物

4

反応物 1

HCID 178428840HCID 178428840、化合物

生成物 1

HCID 178428839HCID 178428839、化合物収率 111.4%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A solution of 3 g (10.5 mmol) of 7-benzyloxy-2-methyl-quinolin-4-ol, product of example 1 c), dissolved in 270 ml of MeOH was treated with 1 g of palladium on charcoal (10%) and then hydrogenated at RT for 1 h until HPLC analysis indicated the completion of the reaction. The catalyst was filtered off, washed with MeOH, and the solution was concentrated in vacuo. The residue was triturated with ether, collected by filtration and dried in a high vacuum to give 2.05 g (98.6%) 2-methyl-quinoline-4,7-diol as an off-white solid. ISP mass spectrum, m/e: 176.2 (M+1 calculated for C10H9NO2: 176).

後処理

  1. customthe completion of the reaction
  2. filtrationThe catalyst was filtered off
  3. washwashed with MeOH
  4. concentrationthe solution was concentrated in vacuo
  5. customThe residue was triturated with ether
  6. filtrationcollected by filtration
  7. customdried in a high vacuum

出典と根拠

ORDレコード
ord-c1c7d703a2f04f74b0c31d78b23fe05f
出典データセット
uspto-grants-2004_11
特許番号
US06818767B2

反応ノート

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