Benzamide → n-(4,7-Dichloroquinolin-2-yl)benzamide

HRID 2415619

反応式

HRID 2415619 の反応式
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([Cl:12])=[CH:9][CH:10]=2)[N+:5]([O-])=[CH:4][CH:3]=1.C(Cl)(=O)C1C=CC=CC=1.[C:23]([NH2:31])(=[O:30])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>>[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([Cl:12])=[CH:9][CH:10]=2)[N:5]=[C:4]([NH:31][C:23](=[O:30])[C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH:3]=1

参加物

4

反応物 3

HCID 2331BenzamideHCID 7412Benzoyl chlorideHCID 2800964,7-Dichloroquinoline 1-oxide

生成物 1

HCID 22641855n-(4,7-Dichloroquinolin-2-yl)benzamide

実験手順

A mixture of example 289A (10.0 g, 46.7 mmol) and benzoyl chloride (23.5 g, 168 mmol) and benzamide (5.9 g, 49.1 mmol) was heated at 180° C. for 6 hours, cooled to room temperature, filtered. Yellow solid as washed with large quantity of water and ethyl acetate (20 mL) and dried under vacuum. MS (ESI(+)Q1MS m/z 318 (M+H)+.

後処理

  1. filtrationfiltered
  2. washYellow solid as washed with large quantity of water and ethyl acetate (20 mL)
  3. customdried under vacuum

出典と根拠

ORDレコード
ord-85b015ad3d3f45328b92e2cccd4524f9
出典データセット
uspto-grants-2004_11
特許番号
US06818772B2

関連ノート

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