Triethylamine → N'-Hydroxy-6-methyl-3-pyridazinecarboximidamide
反応式
[C:1]([C:3]1[N:4]=[N:5][C:6]([CH3:9])=[CH:7][CH:8]=1)#[N:2].Cl.[NH2:11][OH:12].C(N(CC)CC)C>CO>[OH:12][N:11]=[C:1]([C:3]1[N:4]=[N:5][C:6]([CH3:9])=[CH:7][CH:8]=1)[NH2:2]参加物
5
実験手順
3-Cyano-6-methyl pyridazine (U.S. Pat. No. 5,914,319) (0.77 g, 6.4 mmol) was dissolved in methanol (20 mL), then hydroxylamine hydrochloride (0.66 g, 9.6 mmol) and triethylamine (1.3 mL, 9.6 mmol) were added and the mixture was stirred at room temperature overnight. The mixture was chilled in an ice-bath, then the solid was collected by filtration, washed with methanol and dried to give the title compound as a pale yellow solid (0.84 g).
後処理
- temperatureThe mixture was chilled in an ice-bath
- filtrationthe solid was collected by filtration
- washwashed with methanol
- customdried
出典と根拠
- ORDレコード
- ord-cda37a2c2645428fb511e980785d23db
- 出典データセット
- uspto-grants-2004_11
- 特許番号
- US06821972B2
反応ノート
読み込み中…