Triethylamine → N'-Hydroxy-3-(methylamino)-2-pyrazinecarboximidamide
反応式
[CH3:1][NH:2][C:3]1[C:8]([C:9]#[N:10])=[N:7][CH:6]=[CH:5][N:4]=1.C(N(CC)CC)C.Cl.[NH2:19][OH:20]>CO>[OH:20][N:19]=[C:9]([C:8]1[C:3]([NH:2][CH3:1])=[N:4][CH:5]=[CH:6][N:7]=1)[NH2:10]参加物
5
実験手順
To a solution of 2-methylamino-3-cyanopyrazine (J. Heterocycl. Chem. 1992, 29, 1689-92) (0.37 g, 2.8 mmol) in methanol (10 mL) was added triethylamine (0.4 mL, 2.8 mmol) followed by hydroxylamine hydrochloride (0.19 g, 2.8 mmol) and the reaction was stirred at room temperature for 4 hours. The mixture was filtered, the filtrate was then evaporated to dryness. The residue was dissolved in ethyl acetate (50 mL) and washed with water (50 mL). The organic layer was dried (MgSO4) and the solvent was removed in vacuo to give the title compound was a white solid (0.45 g).
後処理
- filtrationThe mixture was filtered
- customthe filtrate was then evaporated to dryness
- dissolutionThe residue was dissolved in ethyl acetate (50 mL)
- washwashed with water (50 mL)
- dry with materialThe organic layer was dried (MgSO4)
- customthe solvent was removed in vacuo
出典と根拠
- ORDレコード
- ord-d920da5ca2c3439ea36a9f1d6e43b2c7
- 出典データセット
- uspto-grants-2004_11
- 特許番号
- US06821972B2
反応ノート
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