Sodium borohydride → HCID 22630832、化合物
反応式
[BH4-].[Na+].[N:3]1[CH:8]=[CH:7][CH:6]=[C:5]([C:9]2[CH:14]=[CH:13][C:12](/[CH:15]=[CH:16]/[CH:17]=[O:18])=[CH:11][CH:10]=2)[N:4]=1>C(O)C>[N:3]1[CH:8]=[CH:7][CH:6]=[C:5]([C:9]2[CH:14]=[CH:13][C:12](/[CH:15]=[CH:16]/[CH2:17][OH:18])=[CH:11][CH:10]=2)[N:4]=1参加物
4
実験手順
Sodium borohydride (90 mg, 2.38 mmol) was added to a suspension of (2E)-3-[4-(3-pyridazinyl)phenyl]-2-propenal (400 mg, 1.90 mmol, prepared as described in Reference Example 61) in ethanol (5 mL) maintained in a room temperature water bath. After 20 min, the reaction was quenched with water (10 mL), allowed to stir for 10 min, and then concentrated to remove the ethanol. The solids were removed by filtration, washed with water, and dried in vacuo to provide 360 mg (89%) of the title compound. MS 213 (M+H)+.
後処理
- customthe reaction was quenched with water (10 mL)
- concentrationconcentrated
- customto remove the ethanol
- customThe solids were removed by filtration
- washwashed with water
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-080c5561334e415f8ff44ec257d4fe62
- 出典データセット
- uspto-grants-2004_11
- 特許番号
- US06825170B2
反応ノート
読み込み中…