Sodium borohydride → 3-(4-(2-Pyrazinyl)phenyl)prop-2-en-1-ol

HRID 2416565ノート

反応式

HRID 2416565 の反応式
[BH4-].[Na+].[N:3]1[CH:8]=[CH:7][N:6]=[C:5]([C:9]2[CH:14]=[CH:13][C:12](/[CH:15]=[CH:16]/[CH:17]=[O:18])=[CH:11][CH:10]=2)[CH:4]=1>C(O)C>[N:6]1[CH:7]=[CH:8][N:3]=[CH:4][C:5]=1[C:9]1[CH:10]=[CH:11][C:12]([CH:15]=[CH:16][CH2:17][OH:18])=[CH:13][CH:14]=1

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 22631067(2E)-3-[4-(3-pyrazinyl)phenyl]-2-propenal

生成物 1

HCID 697135193-(4-(2-Pyrazinyl)phenyl)prop-2-en-1-ol収率 89.3%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Sodium borohydride (90 mg, 2.38 mmol) was added to a suspension of (2E)-3-[4-(3-pyrazinyl)phenyl]-2-propenal (400 mg, 1.90 mmol, prepared as described in Reference Example 18) in ethanol (5 mL) maintained in a room temperature water bath. After 20 min, the reaction was quenched with water (10 mL), allowed to stir for 10 min, and then concentrated to remove the ethanol. The solids were removed by filtration, washed with water, and dried in vacuo to provide 360 mg (89%) of the title compound. MS 213 (M+H)+.

後処理

  1. customthe reaction was quenched with water (10 mL)
  2. concentrationconcentrated
  3. customto remove the ethanol
  4. customThe solids were removed by filtration
  5. washwashed with water
  6. customdried in vacuo

出典と根拠

ORDレコード
ord-25886b0cbfaa43a78a47da7d28b3a119
出典データセット
uspto-grants-2004_11
特許番号
US06825172B2

反応ノート

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