HCID 22632871、化合物 → HCID 22632891、化合物
反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:17]3[C:12](=[CH:13][C:14]([F:31])=[C:15]([N:18]4[CH2:22][CH2:21][CH:20]([NH:23][C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])[CH2:19]4)[CH:16]=3)[C:11](=[O:32])[N:10]([O:33]CC3C=CC=CC=3)[C:9]2=[O:41])=[CH:4][CH:3]=1>[Pd]>[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:17]3[C:12](=[CH:13][C:14]([F:31])=[C:15]([N:18]4[CH2:22][CH2:21][CH:20]([NH:23][C:24]([O:26][C:27]([CH3:30])([CH3:29])[CH3:28])=[O:25])[CH2:19]4)[CH:16]=3)[C:11](=[O:32])[N:10]([OH:33])[C:9]2=[O:41])=[CH:4][CH:3]=1参加物
3
実験手順
Using the General Method 6A, the reaction of 10% Pd/C (0.075 g) with 1-(4-fluorophenyl)-6-fluoro-3-benzyloxy-7-(3-t-butoxycarbonylamino-pyrrolidin-1-yl)-1H-quinazoline-2,4-dione (Example N-1, 0.225 g, 0.4 mmol) afforded 0.182 g of 1-(4-fluorophenyl)-6-fluoro-3-hydroxy-7-(3-t-butoxycarbonylamino-pyrrolidin-1-yl)-1H-quinazoline-2,4-dione.
出典と根拠
- ORDレコード
- ord-70857dc4f56544a0896d3e1023dd301f
- 出典データセット
- uspto-grants-2004_11