3-Isopropylidene-4-methoxy-1,3-dihydro-indol-2-one → 3-Isopropyl-4-methoxy-1,3-dihydro-indol-2-one

HRID 2416935ノート

反応式

HRID 2416935 の反応式
[C:1](=[C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][C:11]=2[O:13][CH3:14])[NH:6][C:5]1=[O:15])([CH3:3])[CH3:2]>[Pd].C(O)C>[CH:1]([CH:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][C:11]=2[O:13][CH3:14])[NH:6][C:5]1=[O:15])([CH3:3])[CH3:2]

参加物

4

反応物 1

HCID 219232453-Isopropylidene-4-methoxy-1,3-dihydro-indol-2-one

生成物 1

HCID 219232483-Isopropyl-4-methoxy-1,3-dihydro-indol-2-one収率 80.2%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A mixture of 3-isopropylidene-4-methoxy-1,3-dihydro-indol-2-one (700 mg, 3.4 mmol) and 5% palladium on carbon (88 mg) in ethanol (25 mL) is hydrogenated at 60 psi overnight. Filtration and removal of the solvent in vacuo provided 560 mg (79%) of 3-isopropyl-4-methoxy-1,3-dihydro-indol-2-one. MS (ESI+) 206.

後処理

  1. customis hydrogenated at 60 psi overnight
  2. filtrationFiltration and removal of the solvent in vacuo

出典と根拠

ORDレコード
ord-2624576942b34f288dd3f068d430eac5
出典データセット
uspto-grants-2004_11
特許番号
US06825220B2

反応ノート

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