Acetonitrile → HCID 15688742、化合物
反応式
I[Si](C)(C)C.C(#N)C.[Cl:9][CH2:10][CH2:11][CH2:12][C:13]([CH3:20])([CH3:19])[C:14]([O:16]CC)=[O:15]>O>[Cl:9][CH2:10][CH2:11][CH2:12][C:13]([CH3:20])([CH3:19])[C:14]([OH:16])=[O:15]参加物
5
反応条件
- 温度
- 80 °C
実験手順
Iodotrimethylsilane (3.00 g, 15 mmols) was added to an acetonitrile solution (5 ml) of ethyl 5-chloro-2,2-dimethylpentanoate (963 mg, 5 mmols) at room temperature, and heated at 80° C. for 24 hours with stirring. The reaction mixture was poured into water with ice, and extracted with ether. The organic layer was washed with water, and dried with anhydrous magnesium sulfate, and the solvent was evaporated to obtain 0.9 g of 5-chloro-2,2-dimethylpentanoic acid as a brown oil.
後処理
- extractionextracted with ether
- washThe organic layer was washed with water
- dry with materialdried with anhydrous magnesium sulfate
- customthe solvent was evaporated
出典と根拠
- ORDレコード
- ord-68ed247a54704339a08fedca0ee3a31a
- 出典データセット
- uspto-grants-2004_11
- 特許番号
- US06825223B2
反応ノート
読み込み中…