2,2,2-Trifluoroethanol → Oxetane, 3,3-bis[(2,2,2-trifluoroethoxy)methyl]-

温度

85 °C

A 2 L round-bottom flask fitted with a mechanical stirrer, condenser and a thermometer was charged with 3,3-bis-(bromomethyl)oxetane (300 g, 1.2 mol), trifluoroethanol (284 g, 2.8 mol), tetrabutylammonium bromide (39.9 g, 0.12 mol) and water (265 mL). The mixture was heated to 85° C. and a 50% aqueous potassium hydroxide solution (672 g, 5.1 mol) was added via an addition funnel over a period of 3 h. The progress of the reaction was monitored by GLC and when greater than 99% of 3,3-bis-(bromomethyl)oxetane was consumed, the reaction mixture was cooled to room temperature and diluted with water (500 mL). The organic phase was separated and washed with 2% aqueous potassium hydroxide solution (500 mL) and water (500 mL). The crude product was then distilled under reduced pressure (bp=103° C./5 mm/Hg) to give 278 g (80%) of greater than 99% pure (GLC) 3,3-bis-(2,2,2-trifluoroethoxymethyl)oxetane, a colorless oil. Spectral analysis revealed that the product prepared by this process was identical with B6-FOX monomer prepared by Procedure A.

1. customA 2 L round-bottom flask fitted with a mechanical stirrer, condenser
2. customwas consumed
3. temperaturethe reaction mixture was cooled to room temperature
4. additiondiluted with water (500 mL)
5. customThe organic phase was separated
6. washwashed with 2% aqueous potassium hydroxide solution (500 mL) and water (500 mL)
7. distillationThe crude product was then distilled under reduced pressure (bp=103° C./5 mm/Hg)

ORDレコード

ord-282f9f5598ce4f2e9368264b6fd768f5

出典データセット

uspto-grants-2004_11

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US06825316B2