Trifluoroacetic acid → (3-Chloro-benzyl)-(2-piperazin-1-yl-pyrimidin-4-yl)-amine, hydrochloride

反応式

C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[N:19]=[C:18]([NH:20][CH2:21][C:22]3[CH:27]=[CH:26][CH:25]=[C:24]([Cl:28])[CH:23]=3)[CH:17]=[CH:16][N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>>[ClH:28].[Cl:28][C:24]1[CH:23]=[C:22]([CH:27]=[CH:26][CH:25]=1)[CH2:21][NH:20][C:18]1[CH:17]=[CH:16][N:15]=[C:14]([N:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)[N:19]=1

参加物

反応物 2

HCID 6422Trifluoroacetic acid

HCID 695963154-[4-(3-Chloro-benzylamino)-pyrimidin-2-yl]-piperazine-1-carboxylic Acid Tert-Butyl Ester

生成物 1

HCID 131724681(3-Chloro-benzyl)-(2-piperazin-1-yl-pyrimidin-4-yl)-amine, hydrochloride

実験手順

The title compound (4-A) was prepared from 4-[4-(3-chloro-benzylamino)-pyrimidin-2-yl]-piperazine-1-carboxylic acid tert-butyl ester (I-4a) and TFA according to a procedure analogous to that described in Example 3.

出典と根拠

ORDレコード: ord-5a5e08db92ee44cd8db14070a9bd00ff
出典データセット: uspto-grants-2004_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06825198B2

反応ノート

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