Sodium hydride → 5-(4-Chlorophenyl)-3,6-dihydro-2H-1,3,4-oxadiazin-2-one
反応式
[H-].[Na+].[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([C:10](=[N:13][NH:14][C:15]([O:17][CH2:18]C)=[O:16])CO)=[CH:6][CH:5]=1>C(O)C>[Cl:3][C:4]1[CH:5]=[CH:6][C:7]([C:10]2[CH2:18][O:17][C:15](=[O:16])[NH:14][N:13]=2)=[CH:8][CH:9]=1参加物
4
反応条件
- 温度
- 0 °C
実験手順
Sodium hydride (60% in oil, 16 mmoles) is added, in small portions and at ambient temperature, to a solution of the compound obtained in Step B (100.5 mmoles) in ethanol (800 ml). After reacting for 2 hours, the reaction mixture is cooled to 0° C. and stiffing is continued for 30 minutes. The precipitate formed is filtered off, washed with cold ethanol and then dried in vacuo to yield the title product, which is used directly in the next Step.
後処理
- waitstiffing is continued for 30 minutes
- customThe precipitate formed
- filtrationis filtered off
- washwashed with cold ethanol
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-2b7b449cd0a94fb88bc5f0d70a3b0284
- 出典データセット
- uspto-grants-2014_02
- 特許番号
- US08653073B2
反応ノート
読み込み中…