Sodium Sulfate → 2-Hydroxyimino-N-{4-[2-(2-oxo-oxazolidin-3-yl)ethyl]phenyl}acetamide

HRID 241748

反応式

HRID 241748 の反応式
S([O-])([O-])(=O)=O.[Na+].[Na+].[OH2:8].Cl[C:10](Cl)(Cl)[CH:11]=[O:12].[NH2:15][C:16]1[CH:21]=[CH:20][C:19]([CH2:22][CH2:23][N:24]2[CH2:28][CH2:27][O:26][C:25]2=[O:29])=[CH:18][CH:17]=1.Cl.[NH2:31]O>O.Cl>[OH:8][N:31]=[CH:10][C:11]([NH:15][C:16]1[CH:21]=[CH:20][C:19]([CH2:22][CH2:23][N:24]2[CH2:28][CH2:27][O:26][C:25]2=[O:29])=[CH:18][CH:17]=1)=[O:12]

参加物

7

反応物 4

HCID 24436Sodium SulfateHCID 443297Hydroxyamine hydrochlorideHCID 107034763-(2-(4-Aminophenyl)ethyl)-1,3-oxazolidin-2-oneHCID 205283762,2,2-Trichloroacetaldehyde hydrate

生成物 1

HCID 866624332-Hydroxyimino-N-{4-[2-(2-oxo-oxazolidin-3-yl)ethyl]phenyl}acetamide

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid溶媒HCID 962Water溶媒3 回

実験手順

Sodium sulphate (78.3 g) is added to a solution of trichloroacetaldehyde hydrate (32.5 mmoles) in water (100 ml). To the resulting suspension there are added a solution of 3-[2-(4-amino-phenyl)ethyl]oxazolidin-2-one in water (20 ml) and concentrated HCl solution (2.83 ml). A solution of hydroxylamine hydrochloride (95 mmoles) in water (50 ml) is then added. The reaction mixture is heated at reflux for two hours. The mixture is then cooled to ambient temperature. The solid formed is then filtered off, washed with water and dried in vacuo in the presence of P2O5 and at 40° C. overnight to yield the title product, which is used directly in the next Step.

後処理

  1. temperatureThe reaction mixture is heated
  2. temperatureat reflux for two hours
  3. customThe solid formed
  4. filtrationis then filtered off
  5. washwashed with water
  6. dry with materialdried in vacuo in the presence of P2O5 and at 40° C. overnight

出典と根拠

ORDレコード
ord-64e59fa5f1e24f38bf1b501021197d01
出典データセット
uspto-grants-2014_02
特許番号
US08653073B2

関連ノート

読み込み中…