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Bromotrimethylsilane → [2-(4-(4-chlorobenzoyl)-2-oxo-1-[4-(2,5-dihydro-1H-pyrrol-1-ylcarbonyl)benzyl]-2,3,4,5-tetrahydro-1H-benzo-[e][1,4]-diazepin-8-yl)ethyl]phosphonic Acid

HRID 2417491
ノート
印刷プレビュー

反応式

HRID 2417491 の反応式
[Cl:1][C:2]1[CH:45]=[CH:44][C:5]([C:6]([N:8]2[CH2:14][C:13]3[CH:15]=[CH:16][C:17]([CH2:19][CH2:20][P:21](=[O:28])([O:25]CC)[O:22]CC)=[CH:18][C:12]=3[N:11]([CH2:29][C:30]3[CH:35]=[CH:34][C:33]([C:36]([N:38]4[CH2:42][CH:41]=[CH:40][CH2:39]4)=[O:37])=[CH:32][CH:31]=3)[C:10](=[O:43])[CH2:9]2)=[O:7])=[CH:4][CH:3]=1.C[Si](Br)(C)C>C(#N)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([N:8]2[CH2:14][C:13]3[CH:15]=[CH:16][C:17]([CH2:19][CH2:20][P:21](=[O:22])([OH:25])[OH:28])=[CH:18][C:12]=3[N:11]([CH2:29][C:30]3[CH:35]=[CH:34][C:33]([C:36]([N:38]4[CH2:42][CH:41]=[CH:40][CH2:39]4)=[O:37])=[CH:32][CH:31]=3)[C:10](=[O:43])[CH2:9]2)=[O:7])=[CH:44][CH:45]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

4

反応物 2

HCID 76113BromotrimethylsilaneHCID 60123508Diethyl [2-(4-(4-chlorobenzoyl)-2-oxo-1-[4-(2,5-dihydro-1H-pyrrol-1-ylcarbonyl)benzyl]-2,3,4,5-tetrahydro-1H-benzo-[e][1,4]-diazepin-8-yl)ethyl]phosphonate

生成物 1

HCID 22632357[2-(4-(4-chlorobenzoyl)-2-oxo-1-[4-(2,5-dihydro-1H-pyrrol-1-ylcarbonyl)benzyl]-2,3,4,5-tetrahydro-1H-benzo-[e][1,4]-diazepin-8-yl)ethyl]phosphonic Acid

試薬・触媒・溶媒 1

HCID 6342Acetonitrile
溶媒

実験手順

40 mg (0.051 mmol) of diethyl [2-(4-(4-chlorobenzoyl)-2-oxo-1-[4-(2,5-dihydro-1H-pyrrol-1-ylcarbonyl)-benzyl]-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-8-yl)ethyl]phosphonate was dissolved in 10 ml of acetonitrile. 0.15 ml of trimethylsilyl bromide was added to the obtained solution, and they were stirred overnight. The solvent was evaporated, and the obtained crude product was treated in the same manner as in step 3 in Example 1 to obtain the title compound.

後処理

  1. customThe solvent was evaporated
  2. customthe obtained crude product
  3. additionwas treated in the same manner as in step 3 in Example 1

出典と根拠

ORDレコード
ord-6c0a6a58ffb34b6eab5d1a4bf27316c5
出典データセット
uspto-grants-2004_11
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US06825191B2

反応ノート

読み込み中…

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