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Potassium Carbonate → 1-Butyl-3-isopropyl-6-chlorouracil
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Butyl-p-toluenesulfonate | HCID 13066 | — |
| 反応物 | 6-Chloro-3-(propan-2-yl)-1,2,3,4-tetrahydropyrimidine-2,4-dione | HCID 820107 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 1-Butyl-3-isopropyl-6-chlorouracil | HCID 23326877 | 98.1% |
反応手順
16.6 g (0.12 mole) of potassium carbonate and 24 g (0.105 mole) of butyl-p-toluene sulphonate are added to a solution of 19 g (0.10 mole) of 3-isopropyl-6-chlorouracil in 200 ml of dimethyl formamide. The mixture is heated for 1 hour to 80° C. After evaporation of the solvent, the residue is taken up in water, followed by extraction with CH2Cl2. The extract is dried over Na2SO4 and the solvent is evaporated, leaving 24 g of a pale yellow oily product.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04469698 |
| 出典データセット | uspto-grants-1984_09 |
| ORD ID | ord-9a001c07283e4687b98f64344ca0e402 |
| 出典メモ | uspto-grants-1984_09 |