Hydrogen Peroxide → HCID 178456656、化合物

HRID 2417684ノート

反応式

HRID 2417684 の反応式
[C:1]([C:3]1[N:7]([CH2:8][CH2:9][CH3:10])[N:6]=[C:5]([CH3:11])[C:4]=1[NH:12][C:13](=O)[CH3:14])#[N:2].[OH:16]O.O.[OH-].[Na+]>C(O)(=O)C>[CH3:11][C:5]1[C:4]2[N:12]=[C:13]([CH3:14])[N:2]=[C:1]([OH:16])[C:3]=2[N:7]([CH2:8][CH2:9][CH3:10])[N:6]=1

参加物

6

反応物 4

HCID 784Hydrogen PeroxideHCID 962WaterHCID 14798Sodium HydroxideHCID 13338440N-(5-Cyano-3-methyl-1-propyl-1H-pyrazol-4-yl)acetamide

生成物 1

HCID 178456656HCID 178456656、化合物収率 66%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

反応条件

温度
80 °C

実験手順

The above acetamide (16 g, 0.085 mol) is added in portions with stirring at 80° C. to a solution prepared by adding 24 ml of 30% hydrogen peroxide to 200 ml water containing 6 g (0.015 mol) of sodium hydroxide. After stirring at 80° C. for five hours, the mixture is cooled, acidified with acetic acid, and filtered to give 11.6 g (66%) of the title compound, mp 196°-198° C.

後処理

  1. customprepared
  2. stirringAfter stirring at 80° C. for five hours
  3. temperaturethe mixture is cooled
  4. filtrationfiltered

出典と根拠

ORDレコード
ord-23dff3078bfa4139918a573a755e386e
出典データセット
uspto-grants-1984_09
特許番号
US04469868

反応ノート

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