反応式
Cl.C(OCC)C.Cl.[C:8]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]1[N:21]2[CH:22]=[N:23][CH:24]=[C:20]2[CH:19]=[CH:18][CH:17]=1)([OH:10])=[O:9]>C(#N)C>[C:8]([CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]1[N:21]2[CH:22]=[N:23][CH:24]=[C:20]2[CH:19]=[CH:18][CH:17]=1)([OH:10])=[O:9]参加物
5
実験手順
The residue is partitioned between water and methylene chloride after pH is adjusted to 10. The aqueous solution is further washed with chloroform, acidified to pH 1 and again washed with ether and toluene. After pH is adjusted to 5.5, extraction with chloroform gives crude 5-(5-carboxypentyl)imidazo-[1,5-a]pyridine. A solution of the acid in 30 ml of acetonitrile is treated with 5N ethanolic hydrochloric acid. After addition of 25 ml of ethyl ether, 5-(5-carboxypentyl)imidazo[1,5-a]pyridine hydrochloride, melting at 201°-4°, crystallizes. 5-(5-Carboxypentyl)-imidazo[1,5-a]pyridine (example 2) is obtained on neutralization of a methanolic solution of the salt to pH 5.
後処理
- customcrystallizes
出典と根拠
- ORDレコード
- ord-8c13edb20c02457eb70deb949672b44d
- 出典データセット
- uspto-grants-1984_09
- 特許番号
- US04470986
関連ノート
読み込み中…