Sodium borohydride → HCID 20269010、化合物

HRID 2417850ノート

反応式

HRID 2417850 の反応式
[NH:1]1[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][C:7]=2[C:6](=[O:13])[CH2:5][CH2:4][CH2:3][C:2]1=[O:14].[BH4-].[Na+]>C(O)C>[OH:13][CH:6]1[C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=2[NH:1][C:2](=[O:14])[CH2:3][CH2:4][CH2:5]1

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 122264031-Benzazocine-2,6(1H,3H)-dione, 4,5-dihydro-

生成物 1

HCID 20269010HCID 20269010、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of 4,5-dihydro-1-benzazocin-2,6-(1H,3H)dione (14.2 g), Tetrahedron Letters 4079-4082 (1976), and sodium borohydride (1.4 g) in ethanol (720 ml) is stirred at room temperature for 18 hours. The ethanol is removed under reduced pressure, and the residue dissolved in dichloromethane (350 ml). The solution is extracted with 2N hydrochloric acid (2×200 ml) and saturated brine (100 ml), and dried over sodium sulfate. The solvent is removed under reduced pressure to give 6-hydroxy-3,4,5,6-tetrahydro-1-benzazocin-2-(1H)-one.

後処理

  1. customThe ethanol is removed under reduced pressure
  2. dissolutionthe residue dissolved in dichloromethane (350 ml)
  3. extractionThe solution is extracted with 2N hydrochloric acid (2×200 ml) and saturated brine (100 ml)
  4. dry with materialdried over sodium sulfate
  5. customThe solvent is removed under reduced pressure

出典と根拠

ORDレコード
ord-aa6ce958b5ec47e397d293c04fa82adf
出典データセット
uspto-grants-1984_09
特許番号
US04470988

反応ノート

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