4-Nitroindan-1-one → 4-Nitro-2,3-dihydro-1H-inden-1-OL

HRID 241797

反応式

HRID 241797 の反応式
[N+:1]([C:4]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:5]=1[CH2:6][CH2:7][C:8]2=[O:13])([O-:3])=[O:2].[BH4-].[Na+]>CO>[N+:1]([C:4]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:5]=1[CH2:6][CH2:7][CH:8]2[OH:13])([O-:3])=[O:2]

参加物

4

反応物 2

HCID 905634-Nitroindan-1-oneHCID 4311764Sodium borohydride

生成物 1

HCID 131024564-Nitro-2,3-dihydro-1H-inden-1-OL

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
0 °C

実験手順

To a 0° C. solution of 4-nitro-2,3-dihydro-1H-inden-1-one (149 mgs, 0.84 mmol, 1.0 equiv) in MeOH (2 mL) was added NaBH4 (10 mg, 0.26 mmol, 0.33 equiv) as a solid in one portion. After stirring for 1 h at 0° C., the solvent was removed in vacuo, and water (3 mL) was added to the residue. The aqueous suspension was extracted three times with EtOAc, and the combined organic layers were dried over sodium sulfate. The solution was filtered and concentrated in vacuo. The desired product was used without further purification (135 mg, 90%).

後処理

  1. customthe solvent was removed in vacuo, and water (3 mL)
  2. additionwas added to the residue
  3. extractionThe aqueous suspension was extracted three times with EtOAc
  4. dry with materialthe combined organic layers were dried over sodium sulfate
  5. filtrationThe solution was filtered
  6. concentrationconcentrated in vacuo
  7. customThe desired product was used without further purification (135 mg, 90%)

出典と根拠

ORDレコード
ord-40c65f2bfd8e48e4930dc96c60de74c6
出典データセット
uspto-grants-2014_02
特許番号
US08653081B2

関連ノート

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