4-Nitroindan-1-one → 4-Nitro-2,3-dihydro-1H-inden-1-OL
反応式
[N+:1]([C:4]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:5]=1[CH2:6][CH2:7][C:8]2=[O:13])([O-:3])=[O:2].[BH4-].[Na+]>CO>[N+:1]([C:4]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:5]=1[CH2:6][CH2:7][CH:8]2[OH:13])([O-:3])=[O:2]参加物
4
反応条件
- 温度
- 0 °C
実験手順
To a 0° C. solution of 4-nitro-2,3-dihydro-1H-inden-1-one (149 mgs, 0.84 mmol, 1.0 equiv) in MeOH (2 mL) was added NaBH4 (10 mg, 0.26 mmol, 0.33 equiv) as a solid in one portion. After stirring for 1 h at 0° C., the solvent was removed in vacuo, and water (3 mL) was added to the residue. The aqueous suspension was extracted three times with EtOAc, and the combined organic layers were dried over sodium sulfate. The solution was filtered and concentrated in vacuo. The desired product was used without further purification (135 mg, 90%).
後処理
- customthe solvent was removed in vacuo, and water (3 mL)
- additionwas added to the residue
- extractionThe aqueous suspension was extracted three times with EtOAc
- dry with materialthe combined organic layers were dried over sodium sulfate
- filtrationThe solution was filtered
- concentrationconcentrated in vacuo
- customThe desired product was used without further purification (135 mg, 90%)
出典と根拠
- ORDレコード
- ord-40c65f2bfd8e48e4930dc96c60de74c6
- 出典データセット
- uspto-grants-2014_02
- 特許番号
- US08653081B2
反応ノート
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