Hydrogen Bromide → 4-(3-Bromopropyl)phenol

HRID 2417990ノート

反応式

HRID 2417990 の反応式
[BrH:1].O[CH2:3][CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][CH:7]=1>O>[Br:1][CH2:3][CH2:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][CH:7]=1

参加物

4

反応物 2

HCID 260Hydrogen BromideHCID 824523-(4-Hydroxyphenyl)propanol

生成物 1

HCID 148170364-(3-Bromopropyl)phenol収率 84%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To 48% hydrobromic acid solution (110 g) was added 4-(3-hydroxypropyl)phenol (25 g) and heated on a steam bath for 3 hours. After cooling, water (500 ml) was added, the oil was extracted with ether, washed with water and then with dilute sodium bicarbonate solution. The etheral extract was dried over potassium carbonate, evaporated and the residue was distilled in a Kugelrohr apparatus giving 29.6 g (84%) of 4-(3-bromopropyl)phenol, bp 180° (2 mm). The product was 92.6% pure by gas chromatography and mass spectrum was compatible with 4-(3-bromopropyl)phenol.

後処理

  1. temperatureheated on a steam bath for 3 hours
  2. temperatureAfter cooling
  3. extractionthe oil was extracted with ether
  4. washwashed with water
  5. extractionThe etheral extract
  6. dry with materialwas dried over potassium carbonate
  7. customevaporated
  8. distillationthe residue was distilled in a Kugelrohr apparatus

出典と根拠

ORDレコード
ord-7a4a9b68a7b04eec8c287a132d269c07
出典データセット
uspto-grants-1984_09
特許番号
US04471116

反応ノート

読み込み中…