1-Benzyloxy-4-[3-(1-methylethyl)aminopropoxy]benzene → 4-[3-(1-Methylethyl)aminopropoxy]phenol

HRID 2417994ノート

反応式

HRID 2417994 の反応式
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][CH2:16][CH2:17][CH2:18][NH:19][CH:20]([CH3:22])[CH3:21])=[CH:11][CH:10]=1)C1C=CC=CC=1>[Pd].C(O)C>[CH3:22][CH:20]([NH:19][CH2:18][CH2:17][CH2:16][O:15][C:12]1[CH:13]=[CH:14][C:9]([OH:8])=[CH:10][CH:11]=1)[CH3:21]

参加物

4

反応物 1

HCID 133384801-Benzyloxy-4-[3-(1-methylethyl)aminopropoxy]benzene

生成物 1

HCID 133384864-[3-(1-Methylethyl)aminopropoxy]phenol収率 100.8%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

1-Benzyloxy-4-[3-(1-methylethyl)aminopropoxy]benzene (11.5 g) was added to an hydrogenation bottle containing 250 ml of ethanol and hydrogenated over 1 g of 10% palladium on carbon (room temperature; starting pressure of 50 psi). After the theoretical uptake of hydrogen, the mixture was filtered and the solvent distilled in vacuo giving 8.1 g of 4-[3-(1-methylethyl)aminopropoxy]phenol, mp 92°-100° (96.4% pure by gas chromatography). Mass spectrum was compatible.

後処理

  1. filtrationAfter the theoretical uptake of hydrogen, the mixture was filtered
  2. distillationthe solvent distilled in vacuo

出典と根拠

ORDレコード
ord-ee67489265104111977ecff667a4e53b
出典データセット
uspto-grants-1984_09
特許番号
US04471116

反応ノート

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