HCID 20446928、化合物 → 4-[5-(1-Methylethyl)aminopentoxy]phenol

HRID 2417995ノート

反応式

HRID 2417995 の反応式
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([O:15][C:16]2C=[C:20]([NH:22][CH:23]([CH3:25])[CH3:24])[CH:19]=[CH:18][CH:17]=2)=[CH:11][CH:10]=1)C1C=CC=CC=1.[H][H]>C(O)(=O)C.[Pd]>[CH3:25][CH:23]([NH:22][CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][O:15][C:12]1[CH:13]=[CH:14][C:9]([OH:8])=[CH:10][CH:11]=1)[CH3:24]

参加物

5

反応物 2

HCID 20446928HCID 20446928、化合物HCID 178418361HCID 178418361、化合物

生成物 1

HCID 133384884-[5-(1-Methylethyl)aminopentoxy]phenol収率 76.1%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 176Acetic Acid溶媒

実験手順

A solution of 1-benzyloxy-4-[5-(1-methylethyl)aminophenoxy]benzene (24 g) in acetic acid (250 ml) was hydrogenated over 1 g 10% palladium on carbon. After shaking for 0.5 hours at room temperature, the theoretical amount of hydrogen was taken up. The solvent was removed by distillation in vacuo and the residue dissolved in water. The solution was basified with saturated sodium bicarbonate solution and the product was recovered by filtration to give 13.0 g (75%) of 4-[5-(1-methylethyl)aminopentoxy]phenol, mp 95°-99° (95.7% pure by gas chromatography). Mass spectrum was compatible with the expected product.

後処理

  1. customThe solvent was removed by distillation in vacuo
  2. dissolutionthe residue dissolved in water
  3. filtrationthe product was recovered by filtration

出典と根拠

ORDレコード
ord-dd80e40835864255a0bab407d7f2a48c
出典データセット
uspto-grants-1984_09
特許番号
US04471116

反応ノート

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