Isopropylamine → 4-[3-(1-Methylethyl)aminopropyl]phenol

HRID 2417997ノート

反応式

HRID 2417997 の反応式
[CH3:1][CH:2]([NH:4]CCC1C=CC(O)=CC=1)[CH3:3].Br[CH2:15][CH2:16][CH2:17][C:18]1[CH:23]=[CH:22][C:21]([OH:24])=[CH:20][CH:19]=1.C(N)(C)C>>[CH3:1][CH:2]([NH:4][CH2:15][CH2:16][CH2:17][C:18]1[CH:23]=[CH:22][C:21]([OH:24])=[CH:20][CH:19]=1)[CH3:3]

参加物

4

反応物 3

HCID 6363IsopropylamineHCID 4175994-[2-(1-Methylethyl)aminoethyl]phenolHCID 148170364-(3-Bromopropyl)phenol

生成物 1

HCID 204469574-[3-(1-Methylethyl)aminopropyl]phenol収率 97.9%

実験手順

Under the conditions outlined above for the preparation of 4-[2-(1-methylethyl)aminoethyl]phenol, 4-(3-bromopropyl)phenol was reacted with isopropylamine. The crude product was distilled in a Kugelrohr apparatus (150°; 1 mm) and the distillate was crystallized from ether to give 4-[3-(1-methylethyl)aminopropyl]phenol (97.9% pure by gas chromatography).

後処理

  1. distillationThe crude product was distilled in a Kugelrohr apparatus (150°; 1 mm)
  2. customthe distillate was crystallized from ether

出典と根拠

ORDレコード
ord-dd2f28a8c0d1483faea80e8d534fd750
出典データセット
uspto-grants-1984_09
特許番号
US04471116

反応ノート

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