Cysteamine Hydrochloride → HCID 15592296、化合物
反応式
Cl.[NH2:2][CH2:3][CH2:4][SH:5].Cl.[CH3:7][N:8]([CH3:16])[C:9]1[S:10][CH:11]=[C:12]([CH2:14]Cl)[N:13]=1>Cl>[CH3:7][N:8]([CH3:16])[C:9]1[S:10][CH:11]=[C:12]([CH2:14][S:5][CH2:4][CH2:3][NH2:2])[N:13]=1参加物
4
実験手順
Cysteamine hydrochloride (5.24 g; 45.9 mmoles) and 2-dimethylamino-4-chloromethylthiazole hydrochloride (9.8 g; 45.9 mmoles) [prepared from N,N-dimethylthiourea and 1,3-dichloro-2-propanone] were dissolved in 45 ml of concentrated hydrochloric acid and heated at an oil bath temperature of 100° for 96 hours. The mixture was evaporated under reduced pressure and the residue made basic with 40% aqueous NaOH. The aqueous phase was extracted with methyl acetate, dried and evaporated to give the title compound as an oil which was used without further purification in Step B.
後処理
- temperatureheated at an oil bath temperature of 100° for 96 hours
- customThe mixture was evaporated under reduced pressure
- extractionThe aqueous phase was extracted with methyl acetate
- customdried
- customevaporated
出典と根拠
- ORDレコード
- ord-a0732057141d41f5b901fbd67e6d3a42
- 出典データセット
- uspto-grants-1984_09
- 特許番号
- US04471122
反応ノート
読み込み中…