5-Bromo-6-fluoro-2-methylquinoline → 5-Bromo-6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline

HRID 2418238ノート

反応式

HRID 2418238 の反応式
[Br:1][C:2]1[C:11]([F:12])=[CH:10][CH:9]=[C:8]2[C:3]=1[CH:4]=[CH:5][C:6]([CH3:13])=[N:7]2.[H][H]>C(O)(=O)C.[Pt]>[Br:1][C:2]1[C:11]([F:12])=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][CH:6]([CH3:13])[NH:7]2

参加物

5

反応物 2

HCID 130353135-Bromo-6-fluoro-2-methylquinolineHCID 178418361HCID 178418361、化合物

生成物 1

HCID 128968175-Bromo-6-fluoro-2-methyl-1,2,3,4-tetrahydroquinoline

試薬・触媒・溶媒 2

HCID 23939Platinum触媒HCID 176Acetic Acid溶媒

実験手順

To a solution of 20 g of 5-bromo-6-fluoroquinaldine in 150 ml of glacial acetic acid was added 2.0 g of platinum on charcoal. The mixture was hydrogenated on a Paar apparatus at a temperature of about 20° C. until the theoretical amount of hydrogen was taken up. The mixture was then filtered through celite to provide a solution of 5-bromo-6-fluoro-1,2,3,4-tetrahydroquinaldine. Evaporation of the solvent provides the desired intermediate. This intermediate could be used directly in Part C below without purification.

後処理

  1. filtrationThe mixture was then filtered through celite

出典と根拠

ORDレコード
ord-f122e434687145a89306062be3d16f5e
出典データセット
uspto-grants-1984_09
特許番号
US04472407

反応ノート

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