Anthranilic Acid → 11-Oxo-11H-pyrido(2,1-b)quinazoline-8-carboxylic acid

HRID 2419013ノート

反応式

HRID 2419013 の反応式
[C:1]([OH:10])(=O)[C:2]1[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=1)[NH2:4].Cl[C:12]1[CH:20]=[CH:19][C:15]([C:16]([OH:18])=[O:17])=[CH:14][N:13]=1.Cl>C(O)C>[O:10]=[C:1]1[C:2]2[C:3](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:4]=[C:12]2[CH:20]=[CH:19][C:15]([C:16]([OH:18])=[O:17])=[CH:14][N:13]12

参加物

5

反応物 3

HCID 227Anthranilic AcidHCID 313Hydrochloric AcidHCID 792226-Chloronicotinic acid

生成物 1

HCID 19843911-Oxo-11H-pyrido(2,1-b)quinazoline-8-carboxylic acid収率 44.5%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A reaction mixture containing 4.35g (31.8 mmol) of anthranilic acid, 5.00g (31.8 mmol) of 6-chloronicotinic acid, 3ml of conc. HCl and 80ml of ethanol was heated at reflux for 21 hours. The mixture was cooled and filtered to give 3.40g (38.9%) of the expected product, mp. 323°-325° dec. The analytical sample was obtained by recrystallization from methanol-ether, mp. 323°-325° dec.

後処理

  1. temperaturewas heated
  2. temperatureat reflux for 21 hours
  3. temperatureThe mixture was cooled
  4. filtrationfiltered

出典と根拠

ORDレコード
ord-280ff82382ae4e9fa9a94af581211720
出典データセット
uspto-grants-1978_08
特許番号
US04104389

反応ノート

読み込み中…